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感染动力学的实验研究:彭氏横窦吸虫尾蚴对终末宿主的感染

Experimental studies of infection dynamics: infection of the definitive host by the cercariae of Transversotrema patialense.

作者信息

Anderson R M, Whitfield P J, Dobson A P

出版信息

Parasitology. 1978 Oct;77(2):189-200. doi: 10.1017/s0031182000049386.

DOI:10.1017/s0031182000049386
PMID:704148
Abstract

The number of cercariae of Transversotrema patialense which attach to the fish host Brachydanio rerio, during a fixed exposure period, is shown to be directly proportional to cercarial density within an experimental infection arena. The distribution of successful infections/host is shown to change from a random pattern to an over-dispersed form as cercarial exposure density or duration of host exposure to infection increases. A stochastic simulation model is used to demonstrate that small differences in host susceptibility to infection, within a population of hosts, can generate patterns of dispersion in parasite numbers/host similar to those observed in the experimental studies. Differences in host behaviour, during the period of exposure to infection, are thought to generate variability in host susceptibility to cercarial infection.

摘要

在固定暴露期内,附着于鱼类宿主斑马鱼的彭氏横口吸虫尾蚴数量,被证明与实验感染区域内的尾蚴密度成正比。随着尾蚴暴露密度或宿主暴露于感染的持续时间增加,成功感染/宿主的分布从随机模式变为过度分散形式。使用随机模拟模型来证明,在宿主群体中,宿主对感染易感性的微小差异可产生寄生虫数量/宿主的分散模式,类似于在实验研究中观察到的模式。在暴露于感染期间,宿主行为的差异被认为会导致宿主对尾蚴感染的易感性产生变化。

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