亚抑菌浓度青霉素对A组链球菌产生透明质酸酶的影响。

Effect of subminimal inhibitory concentrations of penicillin on hyaluronidase production by group A streptococci.

作者信息

Benchetrit L C, Avelino C C, de Oliveira C M

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981 Dec;251(2):152-6.

Abstract

A sensitive dye-binding assay was employed to study the extracellular hyaluronidase produced by three penicillin-sensitive strains of group A streptococci belonging to M types 4, 24 and 28. Enzyme was produced by all strains at appreciable levels. Subminimal inhibitory concentrations of penicillin in growing cultures increased enzyme production by M types 4 and 24 strains. Growth of the M type 28 R strain with added antibiotic was accompanied by a reduced production of hyaluronidase.

摘要

采用一种灵敏的染料结合测定法，研究了属于M4、M24和M28型的三株青霉素敏感A组链球菌产生的细胞外透明质酸酶。所有菌株均能产生可观水平的酶。在生长培养物中，低于最小抑菌浓度的青霉素可增加M4和M24型菌株的酶产量。添加抗生素培养M28 R型菌株时，透明质酸酶产量降低。