Hall J E, Granger J P
Am J Cardiol. 1982 Apr 21;49(6):1527-9. doi: 10.1016/0002-9149(82)90377-0.
THis study was designed to investigate the mechanisms of captopril's chronic effect on arterial pressure and renal function. In dogs maintained on high sodium intake (250 mEq/day), 6 days of captopril infusion caused no change in arterial pressure, renal hemodynamics, sodium excretion or plasma aldosterone concentration. Infusion of captopril for 7 days also caused no significant changes in arterial pressure or renal function in dogs made hypertensive by chronic infusion of angiotensin II and high sodium intake, a model of hypertension in which plasma renin activity is undetectable and prostaglandin and bradykinin formation may be elevated. In dogs maintained on low sodium intake, chronic infusion of captopril decreased arterial pressure and plasma aldosterone concentration markedly while increasing effective renal plasma flow. Infusion of aldosterone (200 micrograms/day) for 8 days during captopril infusion restored plasma aldosterone concentration but did not significantly change arterial pressure or renal function, indicating that decreased plasma aldosterone concentration did not play a major role in the hypertensive and renal effects of captopril. However, angiotensin II infusion (10 ng/kg/min) for 8 days during captopril infusion restored arterial pressure, plasma aldosterone concentration and renal function toward control levels. These data suggest that the effects of captopril on arterial pressure, renal hemodynamics and electrolyte excretion are mediated primarily by decreased angiotensin II formation.
本研究旨在探讨卡托普利对动脉血压和肾功能的慢性影响机制。在高钠摄入（250 mEq/天）的犬中，输注卡托普利6天对动脉血压、肾血流动力学、钠排泄或血浆醛固酮浓度无影响。在通过慢性输注血管紧张素II和高钠摄入制成高血压的犬中（该高血压模型中血浆肾素活性检测不到，前列腺素和缓激肽生成可能增加），输注卡托普利7天对动脉血压或肾功能也无显著影响。在低钠摄入的犬中，慢性输注卡托普利可显著降低动脉血压和血浆醛固酮浓度，同时增加有效肾血浆流量。在输注卡托普利期间输注醛固酮（200微克/天）8天可恢复血浆醛固酮浓度，但对动脉血压或肾功能无显著影响，表明血浆醛固酮浓度降低在卡托普利的降压和肾脏作用中不起主要作用。然而，在输注卡托普利期间输注血管紧张素II（10 ng/kg/分钟）8天可使动脉血压、血浆醛固酮浓度和肾功能恢复至对照水平。这些数据表明，卡托普利对动脉血压、肾血流动力学和电解质排泄的影响主要是通过减少血管紧张素II的生成介导的。
