卡托普利对高血压患者肾功能的影响。
Effects of captopril on renal function in hypertensive patients.
作者信息
Pessina A C, Semplicini A, Rossi G, Gatta A, Palatini P, Gava R, Casiglia E, Dal Palú C
出版信息
Am J Cardiol. 1982 Apr 21;49(6):1572-3. doi: 10.1016/0002-9149(82)90394-0.
PMID:7041601
Abstract
The effects of captopril (SQ 14225) on renal function were studied in 10 hypertensive patients. After 7 weeks of treatment (75 to 500 mg/day) renal plasma flow was practically unchanged and glomerular filtration rate was only slightly decreased despite a significant decrease in blood pressure. All indexes of glomerular capillary permeability and of tubular anatomic integrity remained normal during the treatment period.
摘要
在10例高血压患者中研究了卡托普利（SQ 14225）对肾功能的影响。经过7周治疗（每日75至500毫克）后，尽管血压显著下降，但肾血浆流量实际上未变，肾小球滤过率仅略有降低。在治疗期间，肾小球毛细血管通透性和肾小管解剖完整性的所有指标均保持正常。
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