Gillis C N, Pitt B R
Annu Rev Physiol. 1982;44:269-81. doi: 10.1146/annurev.ph.44.030182.001413.
Pulmonary biogenic amine clearance is a carrier-mediated drug sensitive process associated with uptake into endothelial cells and subsequent metabolism by monoamine oxidase and other enzymes. Its function seems to be maintenance of arterial circulatory homeostasis by biochemically regulating circulating vasoactive hormones. Numerous pulmonary pathologic conditions are associated with alterations in these functions. However, a more precise physiologic role remains to be defined. Areas for further research include: 1. Comparative studies on the ability of endothelium from extrapulmonary and pulmonary vasculatures to extract and metabolize vasoactive amines and other humoral substances. This work must be done both in intact animals and in isolated cultured endothelium derived from organ microvasculatures. 2. Study of factors (e.g. steroids, development, etc) that may regulate pulmonary metabolic functions. 3. Measurements in humans under various clinical conditions. To this end, indicator dilution estimates and transpulmonary gradients have provided intriguing promise of means to assess endothelial metabolic functions in both normal and injured lung.
肺生物源性胺清除是一个载体介导的药物敏感过程，与胺类物质被内皮细胞摄取以及随后被单胺氧化酶和其他酶代谢有关。其功能似乎是通过对循环血管活性激素进行生化调节来维持动脉循环稳态。许多肺部病理状况都与这些功能的改变有关。然而，其更精确的生理作用仍有待确定。进一步研究的领域包括：1. 对肺外和肺血管内皮提取和代谢血管活性胺及其他体液物质能力的比较研究。这项工作必须在完整动物以及从器官微血管分离培养的内皮细胞中进行。2. 对可能调节肺代谢功能的因素（如类固醇、发育等）的研究。3. 在各种临床状况下对人体进行测量。为此，指示剂稀释估计和跨肺梯度为评估正常和损伤肺中的内皮代谢功能提供了有吸引力的手段。
