疣孢漆斑菌素在大鼠体内的代谢
Metabolism of verruculogen in rats.
作者信息
Perera K P, Day J B, Mantle P G, Rodrigues L
出版信息
Appl Environ Microbiol. 1982 Mar;43(3):503-8. doi: 10.1128/aem.43.3.503-508.1982.
Abstract
Radiolabeled verruculogen was detected in a wide range of body tissues 6 min after intravenous administration, but after a further 20 min it was mainly being excreted via the biliary route. In isolated liver perfusion, [14C]verruculogen was rapidly taken up by the liver and metabolized completely, principally to the related tremorgen TR-2 but also to a desoxy derivative of verruculogen. In addition, a smaller amount of an isomer of TR-2 was detected. These metabolic products were excreted in the bile.
摘要
静脉注射后6分钟，在多种身体组织中检测到放射性标记的疣孢漆斑毒素，但再过20分钟后，它主要通过胆汁途径排泄。在离体肝脏灌注实验中，[14C]疣孢漆斑毒素迅速被肝脏摄取并完全代谢，主要代谢为相关的震颤毒素TR-2，也代谢为疣孢漆斑毒素的脱氧衍生物。此外，还检测到少量TR-2的异构体。这些代谢产物通过胆汁排泄。
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