Bargero G, Capra Marzani M
Arch Sci Med (Torino). 1981 Oct-Dec;138(4):557-70.
An account is given of the clinical and serological associations between diabetes and autoimmune diseases, especially those between diabetes and antihyperoglobulin, antithyroid, anti-intrinsic factor, anticorticoadrenal cell, and anti-nucleic acid autoantibodies. Body fluid antipancreas autoimmunity is examined from various standpoints relating to antipancrease cell antibodies (ICA), autoantibodies against glucagon-secreting cells (ECA) and somatostatin-secreting cells (SCA), and anti-islet cell surface antibodies (McLaren and Lernmark antibodies). Particular attention is directed to ICAs, since these have supplied the background for the recent division of type I diabetes into Ia viral and Ib autoimmune. Stress is laid on both the soundness and the problems forming part of ICAs, since their actual pathogenetic role (cytoplasmic markers?) still has to be determined, even though their persistent and significant association with autoimmune polyendocrinopathies is certain.
本文阐述了糖尿病与自身免疫性疾病之间的临床和血清学关联，特别是糖尿病与抗高球蛋白、抗甲状腺、抗内因子、抗肾上腺皮质细胞和抗核酸自身抗体之间的关联。从与抗胰腺细胞抗体（ICA）、抗胰高血糖素分泌细胞自身抗体（ECA）和抗生长抑素分泌细胞自身抗体（SCA）以及抗胰岛细胞表面抗体（麦克拉伦和勒姆马克抗体）相关的各种角度，对体液抗胰腺自身免疫进行了研究。特别关注ICA，因为它们为近期将I型糖尿病分为Ia型病毒型和Ib型自身免疫型提供了背景。着重强调了ICA既有合理性又存在问题，因为尽管它们与自身免疫性多内分泌腺病持续且显著相关是确定的，但它们实际的致病作用（细胞质标志物？）仍有待确定。
