Drake A J
Basic Res Cardiol. 1982 Jan-Feb;77(1):1-11. doi: 10.1007/BF01908126.
Substrate extraction is the disappearance of a substance from arterial blood into the myocardium, substrate utilization being the combustion of that substrate. The terms used for extraction and utilization are defined. There are many problems of accurately measuring glucose and free fatty acid oxidation. Lactate is the preferred substrate of the normal, blood-perfused heart. If the substrate oxidized affects the myocardial oxygen consumption, this could be of considerable importance under conditions of limited oxygen supply. At present there is conflicting evidence. It may be beneficial to switch the heart from one substrate to another, e.g., from fat to carbohydrate fuels. The conditions of ischaemia and hypoxaemia are not the same, and future investigations should be made under carefully controlled conditions.
底物摄取是指一种物质从动脉血进入心肌而消失，底物利用则是该底物的燃烧。文中对摄取和利用这两个术语进行了定义。准确测量葡萄糖和游离脂肪酸氧化存在许多问题。乳酸是正常血液灌注心脏的首选底物。如果氧化的底物影响心肌耗氧量，那么在氧气供应有限的情况下这可能具有相当重要的意义。目前存在相互矛盾的证据。将心脏的底物从一种转换为另一种，例如从脂肪燃料转换为碳水化合物燃料，可能是有益的。缺血和低氧血症的情况并不相同，未来的研究应在严格控制的条件下进行。
