Hiragun A, Sato M, Mitsui H
Gan. 1981 Dec;72(6):891-7.
A clonal cell line of murine fibroblast (ST 13) undergoes a terminal differentiation into adipose cells in culture. A tumor promoter, 12-O-tetradecanoyl phorbol 13-acetate (TPA), reversibly inhibited the differentiation of ST 13 preadipocytes. The inhibition of differentiation was accompanied by changes in cell morphology and growth properties and by suppression of cellular insulin binding activity. Dexamethasone (DXM) could prevent the inhibition by TPA of preadipocyte differentiation, concomitant with prevention of the morphological changes and an increase in insulin binding activity. TPA-induced plasminogen activator (PA) secretion and DXM-mediated inhibition of PA activity could not be correlated with inhibition/prevention-of-inhibition of differentiation.
鼠成纤维细胞（ST 13）的克隆细胞系在培养过程中会终末分化为脂肪细胞。一种肿瘤启动子，12 - O - 十四烷酰佛波醇13 - 乙酸酯（TPA），可逆转抑制ST 13前脂肪细胞的分化。分化的抑制伴随着细胞形态和生长特性的改变以及细胞胰岛素结合活性的抑制。地塞米松（DXM）可以防止TPA对前脂肪细胞分化的抑制，同时防止形态学变化并增加胰岛素结合活性。TPA诱导的纤溶酶原激活物（PA）分泌以及DXM介导的PA活性抑制与分化的抑制/抑制的预防无关。
