Weill-Thevenet N, Buisson J P, Royer R, Hofnung M
Mutat Res. 1982 Apr;104(1-3):1-8. doi: 10.1016/0165-7992(82)90112-9.
The genetic toxicity of benzofurans and naphthofurans was further examined. (i) Seven new 2-nitronaphthofurans tested give a positive response on strains TA1537, TA1538, TA98, TA100, but not on strain TA1535. This response depends at least partially on the bacterial nitroreductase activities and is decreased in presence of activating mixture from rat liver. (ii) A correlation is observed between the mutagenic potency assayed in the Mutatest and the phage-inducing potency assayed in the Inductest. The relevance of these results and of complementary tests on uvr + Salmonella strains and the Spermatest are briefly discussed in perspective of the possible genetic toxicity of the compounds on mammals.
进一步研究了苯并呋喃和萘并呋喃的遗传毒性。(i) 对7种新的2-硝基萘并呋喃进行测试，结果显示它们在TA1537、TA1538、TA98、TA100菌株上呈阳性反应，但在TA1535菌株上无此反应。这种反应至少部分取决于细菌的硝基还原酶活性，并且在存在大鼠肝脏活化混合物时会减弱。(ii) 在Mutatest中测定的诱变效力与在Inductest中测定的噬菌体诱导效力之间存在相关性。从这些化合物对哺乳动物可能的遗传毒性角度，简要讨论了这些结果以及对uvr + 沙门氏菌菌株和精子试验的补充试验的相关性。
