Dybing E, Saxholm H J, Aune T, Wirth P J, Thorgeirsson S S
Natl Cancer Inst Monogr. 1981 Dec(58):21-26.
We aimed our studies toward gaining an understanding of some of the reactions and pathways involved in the metabolism and activation of the aromatic diamines used in hair dyes and of phenacetin used in analgesic mixtures. Comparison of the data obtained from human and animal tissues established that animal tissues can serve as suitable models for evaluation of the activity of these compounds in humans.
我们开展研究旨在了解染发剂中使用的芳香族二胺以及止痛合剂中使用的非那西丁的某些代谢和活化反应及途径。对从人体和动物组织获得的数据进行比较后发现，动物组织可作为评估这些化合物在人体中活性的合适模型。
