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支气管-肺部细菌感染的病理生理学与免疫反应(作者译)

[The pathophysiology and immune response to broncho-pulmonary bacterial infections (author's transl)].

作者信息

Perrin-Fayolle M

出版信息

Rev Fr Mal Respir. 1982;10(1):31-43.

PMID:7043673
Abstract

This study is in two parts. The first is devoted to a brief reminder of those situations in which pathogenic microbes invade the respiratory tract and is concerned with: the rapid elimination of the pathogen, thanks to the intervention of the first line of defence of the lung; a delayed elimination which sets in action complementary mechanisms inducing an inflammatory response; the overflow of the defence system with the development of the infectious illness. The second part is devoted to a review of the causes of failure of the defence mechanisms against the microbes. Two series of events are discussed: first constitutional immune deficiency and secondly acquired deficiencies.

摘要

本研究分为两个部分。第一部分简要回顾了致病微生物侵入呼吸道的情况,涉及:由于肺部第一道防线的干预,病原体被迅速清除;延迟清除,此时启动互补机制引发炎症反应;随着传染病的发展,防御系统的失效。第二部分致力于综述针对微生物的防御机制失败的原因。讨论了两类事件:一是先天性免疫缺陷,二是后天获得性缺陷。

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