Hipkiss A R, McKay M J, Daniels R S, Worthington V C, Atkinson E M
Acta Biol Med Ger. 1981;40(10-11):1265-75.
Proteolysis of certain shortened globin chains can proceed in cell-free extracts of rabbit reticulocytes in the absence of ATP. Proteolysis of amino acid analogue-induced abnormal globin chains of normal chain length may be stimulated by ATP, however. The ATP independent degradation of globin cyanogen bromide-peptides appears to require the presence of free, unblocked amino groups in the substrate, has a pH optimum of 7.8 and is inhibited by phenanthroline, cobalt and zinc ions, N-ethylmaleimide and cystamine.
在没有ATP的情况下，某些缩短的珠蛋白链的蛋白水解可以在兔网织红细胞的无细胞提取物中进行。然而，正常链长度的氨基酸类似物诱导的异常珠蛋白链的蛋白水解可能会受到ATP的刺激。珠蛋白溴化氰肽的ATP非依赖性降解似乎需要底物中存在游离的、未被封闭的氨基，其最适pH为7.8，并受到菲咯啉、钴和锌离子、N-乙基马来酰亚胺和胱胺的抑制。
