Beynon R J, Brown C P, Butler P E
Acta Biol Med Ger. 1981;40(10-11):1539-46.
The proteinase inhibitors leupeptin and chymostatin are inactivated by preparations of perfused mouse liver. The inhibitors are degraded maximally at neutral or alkaline pH values. The inactivating enzymes are inhibited by Dip-F and pms-F but not by EDTA, 1,10 phenanthroline or iodoacetic acid. The significance of these results is discussed in terms of the potential of the inhibitors as antiproteolytic drugs.
