正常和去神经支配大鼠比目鱼肌中两类线粒体的钙离子摄取特性
Ca2+-uptake properties of two populations of mitochondria from normal and denervated rat soleus muscle.
作者信息
Joffe M, Savage N, Isaacs H
出版信息
Biochem J. 1981 Dec 15;200(3):671-7. doi: 10.1042/bj2000671.
Abstract
Ultraturrax- and Nagarse-released populations of mitochondria were characterized with respect to their Ca2+-uptake activities (i) by means of the indirect polarographic technique and (ii) directly by the 45Ca Ruthenium Red-quench method of Reed & Bygrave [(1974) Biochem. J. 140, 143-155]. The denervated-muscle subsarcolemmal and intermyofibrillar mitochondrial fractions displayed markedly decreased rates and capacities for Ca2+ uptake compared with their respective controls. The implications of these findings with respect to the process of cell necrosis are discussed.
摘要
利用（i）间接极谱技术和（ii）直接采用里德和拜格雷夫的45Ca钌红猝灭法[（1974年）《生物化学杂志》140卷，143 - 155页]，对经超声破碎仪和纳加酶处理释放出的线粒体群体的钙摄取活性进行了表征。与各自的对照相比，去神经肌肉肌膜下和肌原纤维间线粒体部分的钙摄取速率和能力显著降低。讨论了这些发现对细胞坏死过程的影响。
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