Altman L C, Tompkins L S
Postgrad Med. 1978 Sep;64(3):157-61, 164-5, 167. doi: 10.1080/00325481.1978.11714927.
All antimicrobial drugs may produce toxic and allergic reactions. Penicillins and cephalosporins cause the greatest number of allergic reactions and should not be used for treatment of minor infections in patients with a history of an adverse reaction. If no alternative antibiotic will suffice for treatment of a serious infection, skin testing is necessary. Two commonly used antimicrobials, clindamycin and isoniazid, can have potentially fatal toxic effects.
所有抗菌药物都可能产生毒性和过敏反应。青霉素和头孢菌素引起的过敏反应最多，有不良反应史的患者不应将其用于治疗轻微感染。如果没有其他抗生素足以治疗严重感染，则必须进行皮肤试验。两种常用的抗菌药物，即克林霉素和异烟肼，可能会产生潜在的致命毒性作用。
