Flechner S M, Novick A C, Steinmuller D, Braun W, Buzsta C
J Urol. 1982 Jun;127(6):1084-6. doi: 10.1016/s0022-5347(17)54238-x.
We reviewed 100 consecutive cadaver renal transplants done at our clinic between April 1976 and October 1979. A minimum 1-year followup was available on all patients. The actual 1-year graft survival rate was 64 per cent and the actual 1-year patient survival rate was 91 per cent. Criteria that had no significant effect on 1-year allograft survival were performance of pre-transplant nephrectomy and/or splenectomy, red blood cell group or the level of pre-formed antibody. A major determinant of graft survival was the number of blood transfusions received before transplantation. The 1-year graft survival rate was 36 per cent with no pre-transplant transfusions, 64 per cent with 1 to 5 transfusions and 70 per cent with more than 5 transfusions (p less than 0.005). The 1-year graft survival rate was not influenced by the use of kidneys imported from other states, the use of pediatric cadaver donors 1 to 15 years old or extended renal preservation times. Our experience supports continued regional and national sharing of adult and pediatric cadaver donor kidneys with extended preservation times.
我们回顾了1976年4月至1979年10月间在我们诊所进行的100例连续尸体肾移植手术。所有患者均有至少1年的随访资料。实际1年移植肾存活率为64%，实际1年患者存活率为91%。对1年同种异体移植肾存活无显著影响的标准包括移植前肾切除术和/或脾切除术的实施情况、红细胞血型或预先形成抗体的水平。移植肾存活的一个主要决定因素是移植前接受输血的次数。未进行移植前输血的患者1年移植肾存活率为36%，接受1至5次输血的患者为64%，接受超过5次输血的患者为70%（p<0.005）。1年移植肾存活率不受使用从其他州进口的肾脏、使用1至15岁小儿尸体供体或延长肾脏保存时间的影响。我们的经验支持继续在区域和全国范围内共享成人和小儿尸体供肾，并延长保存时间。
