Jensen J, Balish E, Mizutani K, Uehling D T
J Urol. 1982 Jun;127(6):1220-2. doi: 10.1016/s0022-5347(17)54301-3.
The resolution of an Escherichia coli urinary tract infection in the bladder and kidneys of control and immunized rats was used to assess their resistance to experimentally induced infection. Prior intravesical immunization of rats with formalin killed E. coli 06 resulted in faster resolution of an infection that had been induced with viable E. coli 06 than was observed in nonimmunized controls. The faster resolution of infection after immunization correlates with our previous findings of decreased adherence of bacteria to urothelium of immunized rats and supports the hypothesis that local immune responses in the urinary tract may play a role in resistance to recurrent urinary tract infections.
通过对照大鼠和免疫大鼠膀胱及肾脏中大肠杆菌尿路感染的消退情况，来评估它们对实验性诱导感染的抵抗力。事先用福尔马林灭活的大肠杆菌06对大鼠进行膀胱内免疫，与未免疫的对照相比，在用活的大肠杆菌06诱导感染后，感染的消退更快。免疫后感染消退更快，这与我们之前发现免疫大鼠的细菌对尿道上皮的黏附性降低相符，并支持以下假说：尿路局部免疫反应可能在抵抗复发性尿路感染中发挥作用。
