Efimov A S
Probl Endokrinol (Mosk). 1978 Sep-Oct;24(5):17-25.
A total of 186 close relatives of diabetic patients were investigated in search of methods for prediabetes diagnosis in persons with predisposition to the disease. Nonesterified fatty acids (NEFA), immunoreactive insulin (IRI) content in response to glucose load, and the state of the cardiovascular system, primarily of microcirculation were investigated. Changes in the microcirculation system not infrequently preceded the development of pathological glucose tolerance test. Capillaroscopy, conjunctival biomicroscopy, rheovasography, cytochemical study of the blood cells, determination of muscular circulation, and, in individual cases, electron microscopy of the muscle bioptates, mucous membranes or the skin are referred to sensitive methods of investigation. Along with metabolic shifts in lipid metabolism, such changes were noted in 1/3 of the relatives with normal glucose tolerance tests.
共对186名糖尿病患者的近亲进行了调查，以寻找对该病易感人群的糖尿病前期诊断方法。研究了非酯化脂肪酸（NEFA）、葡萄糖负荷后免疫反应性胰岛素（IRI）含量以及心血管系统状态，主要是微循环状态。微循环系统的变化常常先于病理性糖耐量试验的出现。毛细血管镜检查、结膜生物显微镜检查、血流图检查、血细胞的细胞化学研究、肌肉循环测定，以及个别情况下对肌肉活检组织、黏膜或皮肤的电子显微镜检查，都属于敏感的检查方法。除了脂质代谢的代谢变化外，在糖耐量试验正常的亲属中有三分之一也出现了此类变化。
