Di Padova F, Di Palo F Q, Morandi E, Elli A, Vallino F
Methods Find Exp Clin Pharmacol. 1982;4(1):43-8.
To define the effect of different immunosuppressive treatments on survival of long-term kidney transplant recipients, we have followed, for a period of four years, a group of 18 long-term survivors (more than three years) of kidney transplantation who were subjected to two different corticosteroid regimens (daily or alternate day corticosteroids) plus azathioprine. THis study not only confirms that an alternate day corticosteroid treatment reduces the incidence of infectious episodes and of side effects, but also suggests that it may steadily improve the survival of these patients. One of the six patients who performed an alternate day corticosteroid regimen died and only one lost renal graft function. On the contrary, three of the twelve patients who received daily corticosteroids died of causes related to immunosuppressive treatment, while another five patients lost renal graft function. A very low level of peripheral blood lymphocytes, of early E rosette and E rosette-forming cells was detected in patients who died of causes related to immunosuppressive treatment.
为确定不同免疫抑制治疗对长期肾移植受者存活情况的影响，我们对一组18名肾移植长期存活者（超过三年）进行了为期四年的随访，这些患者接受了两种不同的皮质类固醇治疗方案（每日或隔日使用皮质类固醇）加硫唑嘌呤。这项研究不仅证实隔日皮质类固醇治疗可降低感染性发作和副作用的发生率，还表明其可能稳步改善这些患者的存活率。采用隔日皮质类固醇治疗方案的6名患者中有1人死亡，仅有1人丧失肾移植功能。相反，接受每日皮质类固醇治疗的12名患者中有3人死于与免疫抑制治疗相关的原因，另有5名患者丧失肾移植功能。在死于与免疫抑制治疗相关原因的患者中，检测到外周血淋巴细胞、早期E玫瑰花结和E玫瑰花结形成细胞水平极低。
