Bury R W, Hale G, Higginbotham M, Mashford M L, Zuidland P
Med J Aust. 1982 Mar 20;1(6):265-7. doi: 10.5694/j.1326-5377.1982.tb132295.x.
We made an open comparison of lignocaine and mexiletine in the treatment of ventricular arrhythmias occurring after open-heart surgery. Thirty patients whose arrhythmia did not respond to correction of metabolic disturbances were randomly allocated to receive treatment either with lignocaine or with mexiletine in fixed dosage schedules (15 in each group). Failure to control the rhythm or recurrent abnormality led to administration of a further dose and, if this was unsuccessful, to crossover to the alternative agent. The two drugs were comparable in efficacy, but mexiletine was slightly more effective when administered after lignocaine than the converse.
我们对利多卡因和美西律治疗心脏直视手术后发生的室性心律失常进行了公开比较。30例心律失常对代谢紊乱纠正无反应的患者被随机分配，按照固定剂量方案接受利多卡因或美西律治疗（每组15例）。未能控制节律或出现反复异常导致给予进一步剂量，如果这一方法不成功，则换用另一种药物。两种药物疗效相当，但利多卡因后给予美西律时，美西律的效果略优于相反给药顺序时。
