Doerr-Schott J, Garaud J C
Peptides. 1981;2 Suppl 2:99-107. doi: 10.1016/0196-9781(81)90019-x.
Peptides homologous to the gastro-intestinal hormones, gastrin and cholecystokinin (CCK), are present in the brain. Using immunohistochemistry we localized a neurosecretory system, reacting with antigastrin sera, in the brain of amphibians by light and electron microscopy. It has a dual location: (1) in the nucleus infundibularis ventralis (NIV) two groups of perikarya give rise to fibre tracts which join up in the infundibular floor and end in the external zone of the median eminence; (2) in the preoptic area nerve fibres and endings are found near the preoptic recess. At the electron microscope level, the immuno-colloidal-gold method revealed cells characterized by small immunoreactive dense granules, localized in the perikarya, nerve fibres and endings. Specificity controls showed that the immunoreacting substance(s) contain(s) all or part of the sequence (Trp-Met-Asp-Phe) common to gastrin, CCK and pentagastrin. The exact nature(s) and physiological function(s) of these substance(s) has (have) still to be defined.
与胃肠激素胃泌素和胆囊收缩素（CCK）同源的肽存在于大脑中。我们运用免疫组织化学方法，通过光学显微镜和电子显微镜在两栖动物大脑中定位了一个与抗胃泌素血清发生反应的神经分泌系统。它有两个分布位置：（1）在腹侧漏斗核（NIV）中，两组神经核周体发出纤维束，这些纤维束在漏斗底部会合，并终止于正中隆起的外侧区；（2）在视前区，在视前隐窝附近发现了神经纤维和神经末梢。在电子显微镜水平上，免疫胶体金法显示细胞的特征是含有小的免疫反应性致密颗粒，这些颗粒位于神经核周体、神经纤维和神经末梢中。特异性对照表明，免疫反应物质包含胃泌素、CCK和五肽胃泌素共有的全部或部分序列（色氨酸-蛋氨酸-天冬氨酸-苯丙氨酸）。这些物质的确切性质和生理功能仍有待确定。
