Thoeni R F, Moss A A
Radiology. 1982 Jul;144(2):271-5. doi: 10.1148/radiology.144.2.7045975.
Fifteen healthy volunteers underwent a randomized trial of oral cholecystography (OCG) using 5 different combinations of contrast agents given as 2 consecutive doses: Telepaque (iopanoic acid) given with food (TF) or without food (T), Bilopaque (sodium tyropanoate) given without food, and a combination of both agents (TF-B). The density of gallbladder opacification was judged visually on a scale of 1+ to 4+ and quantitatively by a densitometric method. Comparison of gallbladder opacification on the first and second days of the study revealed 52 of 75 (70%) combinations (TF-T, TF-TF,T-T, TF-B, B-B) resulted in improved opacification, 17% in equal opacification, and 13% in worse opacification on day 2. The TF-B combination showed the highest number (9) of excellent (grade 4+) results and the lowest number (2) of poor (grade 1+ and 2+) results, gave the best opacification in 8 volunteers, and had the highest average density difference (0.32) between first- and second-day opacifications. The TF-TF combination was the next most effective, and the T-T combination was the least effective. The results indicate that OCG in 2 consecutive doses is superior to single-dose OCG, and that a combination of TF-B or TF-TF will provide the greatest gallbladder opacification. The TF-B combination is recommended because of better patient tolerance.
15名健康志愿者参与了一项口服胆囊造影术（OCG）的随机试验，试验使用5种不同造影剂组合，分连续2剂给药：Telepaque（碘番酸）与食物同服（TF）或不同服（T），Bilopaque（酪氨酸钠）不同服，以及两种造影剂联合使用（TF-B）。通过视觉将胆囊显影密度按1+至4+分级判断，并采用密度测定法进行定量分析。研究第一天和第二天胆囊显影情况比较显示，75种组合（TF-T、TF-TF、T-T、TF-B、B-B）中有52种（70%）显影改善，17%显影相同，13%在第二天显影变差。TF-B组合优秀（4+级）结果数量最多（9个），差（1+和2+级）结果数量最少（2个），8名志愿者显影最佳，第一天和第二天显影的平均密度差最高（0.32）。TF-TF组合次之，T-T组合效果最差。结果表明，连续2剂口服胆囊造影术优于单剂口服胆囊造影术，TF-B或TF-TF组合胆囊显影最佳。因患者耐受性较好，推荐使用TF-B组合。
