Pegels J G, Bruynes E C, Korthals Altes H R, Engelfriet C P, von dem Borne A E
Vox Sang. 1982;42(4):211-6.
Both 51Cr-survival studies with donor platelets and allogenic skin transplantations were performed in a patient with immune unresponsiveness to platelet antigens, i.e., HLA-and platelet-specific antigens. The patients, who suffered from hypoplastic anaemia, was successfully transfused with random donor platelets during 13 months. The serum of this patient contained only granulocyte-and mononuclear-cell-reactive antibodies, but no platelet-reactive antibodies. A nearly normal survival time of the donor platelets as well as a prolonged rejection time of a skin allograft of the same donor support the serological findings. The 51Cr-platelet survival time was not influenced by a leucocyte concentrate from the same donor, which was administered at the same time. Thus, in our patient, no increased platelet destruction could be induced via the so-called innocent bystander mechanism.
对一名对血小板抗原（即人类白细胞抗原和血小板特异性抗原）免疫无反应的患者进行了供体血小板的⁵¹Cr存活研究和同种异体皮肤移植。该患者患有再生障碍性贫血，在13个月内成功输注了随机供体血小板。该患者的血清仅含有粒细胞和单核细胞反应性抗体，而无血小板反应性抗体。供体血小板的存活时间接近正常，以及来自同一供体的皮肤同种异体移植物的排斥时间延长，均支持血清学检查结果。⁵¹Cr血小板存活时间不受同时给予的来自同一供体的白细胞浓缩物的影响。因此，在我们的患者中，无法通过所谓的无辜旁观者机制诱导血小板破坏增加。
