Májský A, Fortýnová J, Vopatová M
Folia Haematol Int Mag Klin Morphol Blutforsch. 1981;108(6):831-7.
In 37 patients with thrombocytopenia (mostly with ITP) the survival time of 51Cr-labeled allogeneic platelets was investigated. The HLA antigens were typed in donors and recipients and the presence of HLA cytotoxins and specific thrombocyte antibodies in sera of patients were examined. In 7 cases the identity of 2 HLA antigens, in 15 cases that of 1 HLA antigen and in 15 cases the HLA incompatibility between donor and patient were found. The survival of platelets did not depend on the degree of HLA compatibility, unless the HLA cytotoxins in sera of patients appeared. The HLA, as well the specific platelet antibodies brought about the shortened platelet survival to 1 day and less. The importance of these observations for platelet kinetics is discussed.
对37例血小板减少症患者（大多为特发性血小板减少性紫癜患者）进行了51Cr标记的同种异体血小板存活时间的研究。对供体和受体进行了HLA抗原分型，并检测了患者血清中HLA细胞毒素和特异性血小板抗体的存在情况。发现7例有2种HLA抗原相同，15例有1种HLA抗原相同，15例供体与患者之间存在HLA不相容性。血小板的存活并不取决于HLA相容程度，除非患者血清中出现HLA细胞毒素。HLA以及特异性血小板抗体可使血小板存活时间缩短至1天及更短。讨论了这些观察结果对血小板动力学的重要性。
