Bardo M T, Hughes R A
Pharmacol Biochem Behav. 1978 Jul;9(1):147-9. doi: 10.1016/0091-3057(78)90027-8.
Morphine influence on a flight response elicited by wing shock was examined in 17-day-old chickens. The chickens received either morphine (30 mg/kg) or saline on two days and were tested for responsivity to wing shock 30 min after each injection. On a third day all chickens received saline injections and were tested again. Tests consisted of delivering wing shock at increasing intensity to determine the threshold of a species-typical flight response. Morphine significantly increased the flight response th reshold on the first test (analgesia), but not on the second test. Shock intensity values required to elicit the flight response in morphine and saline groups did not differ significantly on the third test when all birds received saline. In contrast to previous evidence, these results demonstrate morphine analgesia in chickens using a dose that approximates the analgesic dose range reported for other species.
在17日龄的雏鸡中研究了吗啡对翅膀电击引发的飞行反应的影响。雏鸡在两天内分别接受吗啡(30毫克/千克)或生理盐水注射,并在每次注射后30分钟测试其对翅膀电击的反应性。在第三天,所有雏鸡都接受生理盐水注射并再次进行测试。测试包括以递增强度施加翅膀电击,以确定典型物种飞行反应的阈值。吗啡在第一次测试中显著提高了飞行反应阈值(镇痛作用),但在第二次测试中没有。当所有鸟类都接受生理盐水时,在第三次测试中,吗啡组和生理盐水组引发飞行反应所需的电击强度值没有显著差异。与先前的证据相反,这些结果表明,使用接近其他物种报道的镇痛剂量范围的剂量,吗啡对雏鸡具有镇痛作用。