Resnick S I, Hernandez L, Chen J, Hoebel B G
Pharmacology. 1978;17(3):157-62. doi: 10.1159/000136849.
Phenylpropanolamine hydrochloride (PPA) is a widely used decongestant and anorectic drug. The present study investigated the hypoglycemic effects of intraperitoneal PPA on rats to test the possibility that it might derive some of its anorectic properties through effects on glucostatic mechanisms. PPA tended to lower blood glucose levels in normal rats; the glycemia reducing effect was larger and statistically significant in rats made hyperglycemic by prior treatment with streptozocin to cause diabetes. This is the first evidence that PPA migh possibly reduce feeding by increasing blood sugar utilization.
盐酸苯丙醇胺（PPA）是一种广泛使用的减充血剂和食欲抑制剂。本研究调查了腹腔注射PPA对大鼠的降血糖作用，以测试其可能通过影响糖稳态机制而产生一些食欲抑制特性的可能性。PPA倾向于降低正常大鼠的血糖水平；在先前用链脲佐菌素治疗致糖尿病而导致高血糖的大鼠中，血糖降低作用更大且具有统计学意义。这是PPA可能通过增加血糖利用来减少进食的首个证据。
