大鼠脂肪细胞对葡萄糖和果糖摄取的比较。
Comparison of glucose and fructose transport into adipocytes of the rat.
作者信息
Halperin M L, Cheema-Dhadli S
出版信息
Biochem J. 1982 Mar 15;202(3):717-21. doi: 10.1042/bj2020717.
The purpose of these studies was to define the properties of the systems that transport hexoses into adipocytes. Glucose appears to enter adipocytes on a single transport system whose maximum velocity is stimulated by insulin and which is competitively inhibited by cytochalasin B, 5-thioglucose, fructose, mannose and 3-O-methylglucose. In contrast, fructose enters adipocytes by at least two separate mechanisms, one an insulin-sensitive transporter (probably the glucose transporter) and the other a mechanism that is insensitive to insulin. The fructose concentration required for half-maximal rates of transport is at least an order of magnitude higher than that for glucose and the maximum velocity of fructose transport is more than double that for glucose.
这些研究的目的是确定将己糖转运到脂肪细胞中的系统的特性。葡萄糖似乎通过单一转运系统进入脂肪细胞，该系统的最大转运速度受胰岛素刺激，并受到细胞松弛素B、5-硫代葡萄糖、果糖、甘露糖和3-O-甲基葡萄糖的竞争性抑制。相比之下，果糖通过至少两种不同的机制进入脂肪细胞，一种是胰岛素敏感转运体（可能是葡萄糖转运体），另一种是对胰岛素不敏感的机制。达到转运速率半最大值所需的果糖浓度比葡萄糖至少高一个数量级，果糖转运的最大速度是葡萄糖的两倍多。
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