一种胸腺因子（胸腺刺激素）对未经治疗的霍奇金病患者免疫参数的体内作用。

The in vivo effect of a thymic factor (thymostimulin) on immunologic parameters of patients with untreated Hodgkin's disease.

作者信息

Martelli M F, Velardi A, Rambotti P, Cernetti C, Bertotto A, Spinozzi F, Bracaglia A M, Falini B, Davis S

出版信息

Cancer. 1982 Aug 1;50(3):490-7. doi: 10.1002/1097-0142(19820801)50:3<490::aid-cncr2820500318>3.0.co;2-m.

DOI:10.1002/1097-0142(19820801)50:3<490::aid-cncr2820500318>3.0.co;2-m

Abstract

The in vivo effect of a calf thymus extract (thymostimulin, TS) on the E-rosetting capacity, PHA blastogenic response, serum migration inhibitory activity (LIF) and skin reactivity to recall antigens was evaluated in 19 untreated patients with Hodgkin's disease. In patients the mean percentage of peripheral blood lymphocytes forming E-rosettes increased from 47 to 55.7% (P less than or equal to 0.001; normal: 58.9). The mean PHA stimulation index rose with all three concentrations tested but did not reach normal values. Serum LIF was positive in only one patient prior to treatment with a mean LIF for all patients of 0.75 (P less than or equal to 0.005). Skin tests were positive in ten patients (52.6%) prior to therapy and 18 patients following therapy (94.7%; P less than or equal to 0.05). Thymostimulin, in vivo, appears to return immunologic competency to a population of untreated patients with Hodgkin's disease.

摘要

在19例未经治疗的霍奇金病患者中评估了小牛胸腺提取物（胸腺刺激素，TS）对E玫瑰花结形成能力、PHA促有丝分裂反应、血清迁移抑制活性（LIF）以及对回忆抗原的皮肤反应性的体内效应。患者外周血淋巴细胞形成E玫瑰花结的平均百分比从47%增加至55.7%（P≤0.001；正常：58.9）。用所测试的所有三种浓度的PHA刺激后，平均刺激指数均升高，但未达到正常值。治疗前仅1例患者血清LIF呈阳性，所有患者的平均LIF为0.75（P≤0.005）。治疗前10例患者（52.6%）皮肤试验呈阳性，治疗后18例患者（94.7%；P≤0.05）呈阳性。胸腺刺激素在体内似乎能使一群未经治疗的霍奇金病患者恢复免疫能力。