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大鼠脾脏和腘淋巴结中免疫复合物捕获的个体发生学方面

Ontogenetic aspects of immune-complex trapping in the spleen and popliteal lymph nodes of the rat.

作者信息

Dijkstra C D, van Tilburg N J, Döpp E A

出版信息

Cell Tissue Res. 1982;223(3):545-52. doi: 10.1007/BF00218475.

DOI:10.1007/BF00218475
PMID:7046945
Abstract

An ontogenetic approach was used to obtain information about the relation between structure and function of lymphoid tissues. In particular the development of the capacity to trap immune complexes was studied in relation to the development of the lymphoid compartments. For this purpose isologous horseradish (HRP)-ant-HRP complexes were injected into neonatal rats, and their fate was studied in the spleen and popliteal lymph nodes. Immune-complex trapping occurred as soon as primary follicles could be recognized; without follicles no trapping was observed. Several explanations for this simultaneous development of trapping capacity and follicular structure are discussed.

摘要

采用个体发生学方法来获取有关淋巴组织结构与功能之间关系的信息。特别研究了捕获免疫复合物能力的发育与淋巴区室发育的关系。为此，将同源辣根过氧化物酶（HRP）-抗-HRP复合物注射到新生大鼠体内，并在脾脏和腘淋巴结中研究其命运。一旦能够识别初级滤泡，就会发生免疫复合物捕获；没有滤泡则未观察到捕获现象。本文讨论了捕获能力和滤泡结构同时发育的几种解释。

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