Shatney C H, Lillehei R C, Dietzman R H, Romero L H, Beckman C B
Circ Shock. 1982;9(3):247-58.
Using closed chest coronary artery microsphere embolization, myocardial infarction and subsequent shock were produced in healthy adult mongrel dogs. Following infarction animals were distributed among the following groups: (1) control; (2) methylprednisolone sodium succinate (MPSS); (3) methylprednisolone sodium phosphate (MPSP); (4) sodium phosphate (SP); and (5) sodium succinate (SS). Drug doses of equivalent anti-inflammatory activity were administered i.v. 15 min after infarction. Compared to control animals, only dogs treated with MPSS exhibited significant improvements in hemodynamic parameters and permanent survival. Survival in MPSS dogs was significantly (P = 0.02) better than that of either group treated with SP or SS and substantially (P = 0.02) better than that of either group treated with SP or SS and substantially (P = 0.065) better than the survival rate of dogs receiving MPSP. It appears that succinate is permissive, while phosphate is restrictive, with respect to efficacy of methylprednisolone in experimental cardiogenic shock. Possible explanations for these observations are discussed.
采用闭胸冠状动脉微球栓塞法，在健康成年杂种犬身上诱发心肌梗死及随后的休克。梗死发生后，将动物分为以下几组：(1)对照组；(2)琥珀酸钠甲泼尼龙(MPSS)；(3)磷酸钠甲泼尼龙(MPSP)；(4)磷酸钠(SP)；(5)琥珀酸钠(SS)。梗死15分钟后静脉注射具有等效抗炎活性的药物剂量。与对照动物相比，仅接受MPSS治疗的犬在血流动力学参数和长期存活方面有显著改善。MPSS组犬的存活率显著(P = 0.02)高于接受SP或SS治疗的任何一组，且显著(P = 0.02)高于接受SP或SS治疗的任何一组，并且显著(P = 0.065)高于接受MPSP治疗的犬的存活率。就甲泼尼龙在实验性心源性休克中的疗效而言，琥珀酸盐似乎具有促进作用，而磷酸盐则具有限制作用。文中讨论了对这些观察结果的可能解释。
