[Research in the field of clinical pharmacology in the USSR].

The authors analyze the results of research on clinical pharmacology carried out at various institutions in this country. The overwhelming majority of works are concerned with clinical studies on the pharmacodynamics and pharmacokinetics of the drugs, their interaction, and detection of drug side effects. Special attention is paid to the improvement of the methods for determination of the pharmacological agents in biological fluids, and to the design of the maximally adequate parameters of assessing the pharmacodynamics of the main groups of the drugs. Considerable part of investigations is devoted to clinical pharmacogenetics, chronopharmacology, age pharmacology, prediction of the drug effects, approaches to the extrapolation of experimental data to the clinical trials of the drugs. The authors also provide evidence on the system of clinical trials of new drugs and detection of untoward effects of the medicines used.