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未处理的怀孕小鼠脾脏斑块形成细胞数量随妊娠期延长而增加。

Increase in the number of splenic plaque forming cells with length of gestation in untreated pregnant mice.

作者信息

Mattsson R

出版信息

Dev Comp Immunol. 1982 Spring;6(2):339-48. doi: 10.1016/s0145-305x(82)80017-7.

DOI:10.1016/s0145-305x(82)80017-7
PMID:7047249
Abstract

The number of plaque forming cells (PFC) in spleens from untreated virgin and syngeneically pregnant CBA mice has been evaluated by use of two different hemolytic plaque assays. The total number of splenic IgM- and IgG-PFC in virgin and 16 day pregnant mice was determined by protein A- sheep red blood cell (SRBC) plaque assay. The number of both IgM- and IgG-PFC was significantly increased in spleens from pregnant mice, but the total number of IgM-PFC was several times higher than that of the IgG-PFC. In the same experiment the number of splenic anti-trinitrophenyl (TNP) PFC was determined simultaneously. The values obtained for anti-TNP PFC in the different animals were found to correlate with the values for IgM-PFC in the protein A-SRBC plaque assay. Finally, the number of splenic anti-TNP PFC was determined at different occasions during pregnancy (day 4, 8, 12, and 16). It was found that the number of anti-TNP PFC was elevated as early as the 4th day of pregnancy, and that the number of PFC per spleen increased with the length of gestation.

摘要

通过两种不同的溶血空斑试验，评估了未处理的处女CBA小鼠和同基因怀孕CBA小鼠脾脏中的空斑形成细胞（PFC）数量。采用蛋白A-绵羊红细胞（SRBC）空斑试验测定处女小鼠和怀孕16天小鼠脾脏中IgM-和IgG-PFC的总数。怀孕小鼠脾脏中IgM-和IgG-PFC的数量均显著增加，但IgM-PFC的总数比IgG-PFC高出数倍。在同一实验中，同时测定了脾脏抗三硝基苯（TNP）PFC的数量。发现不同动物中抗TNP PFC的数值与蛋白A-SRBC空斑试验中IgM-PFC的数值相关。最后，在怀孕的不同时期（第4、8、12和16天）测定脾脏抗TNP PFC的数量。发现抗TNP PFC的数量早在怀孕第4天就升高了，并且每个脾脏中PFC的数量随着妊娠期的延长而增加。

相似文献

1
Increase in the number of splenic plaque forming cells with length of gestation in untreated pregnant mice.未处理的怀孕小鼠脾脏斑块形成细胞数量随妊娠期延长而增加。
Dev Comp Immunol. 1982 Spring;6(2):339-48. doi: 10.1016/s0145-305x(82)80017-7.
2
Strain differences in the development of auto-anti-idiotypic antibody regulation with age: genetic linkage to the Igh-C locus.自身抗独特型抗体调节随年龄发展的品系差异：与免疫球蛋白重链恒定区（Igh-C）基因座的遗传连锁
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Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells.在对三硝基苯-聚蔗糖（TNP-ficoll）的正常免疫反应过程中自身抗独特型抗体的产生。I. AKR/J和BALB/c小鼠中半抗原增强的抗TNP噬斑形成细胞的出现及其在免疫脾细胞受体中的加速出现。
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IgG subclass distribution of anti-sheep red blood cell plaque-forming cells in mice with the CBA/N defect.具有CBA/N缺陷的小鼠中抗绵羊红细胞斑块形成细胞的IgG亚类分布
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Production of auto-anti-idiotypic antibody during the normal immune response to TNP-Ficoll. II. Hapten-reversible inhibition of anti-TNP plaque-forming cells by immune serum as an assay for auto-anti-idiotypic antibody.对三硝基苯-聚蔗糖（TNP-Ficoll）正常免疫应答过程中自身抗独特型抗体的产生。II. 用免疫血清对半抗原可逆性抑制抗TNP噬斑形成细胞进行检测以测定自身抗独特型抗体
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The potentiality of antibody-producing cells. I Bispecific cell occurrence in double stimulated cultures of syngeneic or allogeneic spleen cells of the mouse.抗体产生细胞的潜能。I. 小鼠同基因或异基因脾细胞双重刺激培养物中双特异性细胞的出现。
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The immune response of mice treated with anti-mu antibodies: the effect on antibody-forming cells, their precursors and helper cells assayed in vitro.用抗μ抗体处理的小鼠的免疫反应：对体外测定的抗体形成细胞、其前体和辅助细胞的影响。
J Immunol. 1975 Jun;114(6):1808-12.
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Characterization of background anti-trinitrophenyl plaque-forming cells observed in several strains of mice.在几种小鼠品系中观察到的背景抗三硝基苯基空斑形成细胞的特征描述。
Jpn J Microbiol. 1976 Feb;20(1):45-52. doi: 10.1111/j.1348-0421.1976.tb00906.x.

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