McMillan E M, Beeman K, Wasik R, Everett M A
J Am Acad Dermatol. 1982 May;6(5):880-7. doi: 10.1016/s0190-9622(82)70077-5.
Infiltrates of five cases of mycosis fungoides (MF) were studied for the presence of cells reactive with a monoclonal antibody, OKT 6, which detects an antigen present on relatively immature thymocytes and Langerhans cells. In situ immunohistochemical staining was used for their demonstration. OKT 6-reactive cells formed a definite component of the dermal infiltrates of all patients examined. In three patients who showed numerous Pautrier microabscesses on routine histologic examination, OKT 6-positive cells were found to form a component of these abscesses. OKT 6-reactive cells have also recently been shown to be present in varying numbers in the dermal infiltrates of large plaque (atrophic) parapsoriasis (LPAP), a condition which may terminate in MF. The significance of these findings is discussed.
对5例蕈样肉芽肿（MF）的浸润情况进行了研究，以检测与单克隆抗体OKT 6反应的细胞，该抗体可检测相对未成熟胸腺细胞和朗格汉斯细胞上存在的一种抗原。采用原位免疫组织化学染色来显示这些细胞。OKT 6反应性细胞构成了所有受检患者皮肤浸润的一个明确组成部分。在3例常规组织学检查显示有大量帕蒂埃微脓肿的患者中，发现OKT 6阳性细胞构成了这些脓肿的一个组成部分。最近还发现，在大斑块（萎缩性）副银屑病（LPAP）的皮肤浸润中也存在数量不等的OKT 6反应性细胞，LPAP这种疾病可能会发展为MF。本文讨论了这些发现的意义。
