El-Naggar A K, Higashi G I
J Clin Lab Immunol. 1982 May;8(1):37-42.
This study assessed in vivo and in vitro parameters of cell-mediated immunity in 45 tuberculous meningitis patients. Delayed-type hypersensitivity responses to purified protein derivative of tuberculin (PPD), Candida albicans and streptokinase-streptodornase antigens were lacking in 34 patients compared to 2 of 54 normal volunteers. Circulating T lymphocyte subpopulations (E-rosetting active and total T cells) were diminished in 41 patients studied compared to 41 normal donors (p less than 0.001). Lymphocyte blast responses to PPD (25 micrograms-500 micrograms/ml) were positive but quantitatively depressed in all 34 patients studied compared to PPD positive normal donors (p less than 0.001). Phytohemagglutinin responses were significantly depressed (p less than 0.001). Repeat studies in 20 patients 4-5 months post-therapy resulted in reversals of all parameters to control values with heightened blastogenic responses to all PPD concentrations.
本研究评估了45例结核性脑膜炎患者细胞介导免疫的体内和体外参数。与54名正常志愿者中的2人相比，34例患者缺乏对结核菌素纯蛋白衍生物（PPD）、白色念珠菌和链激酶-链道酶抗原的迟发型超敏反应。与41名正常供者相比，在41例接受研究的患者中，循环T淋巴细胞亚群（E花环活性T细胞和总T细胞）减少（p<0.001）。在所有34例接受研究的患者中，对PPD（25微克 - 500微克/毫升）的淋巴细胞增殖反应呈阳性，但与PPD阳性的正常供者相比，在数量上受到抑制（p<0.001）。植物血凝素反应显著降低（p<0.001）。对20例患者在治疗后4 - 5个月进行的重复研究结果显示，所有参数均恢复至对照值，对所有PPD浓度的增殖反应增强。
