Kawata T, Itaya K
Jpn J Pharmacol. 1982 Apr;32(2):255-62. doi: 10.1254/jjp.32.255.
Effects of BCG cells on blood insulin, glucose, glycerol and free fatty acid (FFA), and liver glycogen were examined in rats in vivo. Freund's complete adjuvant (FCA) was used as a solution containing BCG cells. Insulin secretion and lactate production by isoproterenol were enhanced by FCA injection. Hyperglycemia induced by epinephrine was somewhat attenuated by treating rats with FCA. The increment of plasma FFA by isoproterenol was smaller in FAC-injected rats than that in control rats. The amount of glycogen in liver was increased by FCA treatment Anti-insulin antiserum (AIS) did not modify the lactate producing action of isoproterenol. FFA release stimulated by isoproterenol was enhanced by AIS. Liver glycogen content in FCA-injected rats was decreased by AIS injection. These results suggest that some component(s) of BCG cells may enhance insulin release stimulated by secretagogues, and insulin thus released attenuates some metabolic effects of the agonist.
在大鼠体内研究了卡介苗（BCG）细胞对血液胰岛素、葡萄糖、甘油和游离脂肪酸（FFA）以及肝糖原的影响。弗氏完全佐剂（FCA）用作含卡介苗细胞的溶液。注射FCA可增强异丙肾上腺素诱导的胰岛素分泌和乳酸生成。用FCA处理大鼠可使肾上腺素诱导的高血糖症有所减轻。注射FCA的大鼠中，异丙肾上腺素引起的血浆FFA增量比对照大鼠小。FCA处理可增加肝脏糖原含量。抗胰岛素抗血清（AIS）不改变异丙肾上腺素的乳酸生成作用。AIS可增强异丙肾上腺素刺激的FFA释放。注射AIS可使注射FCA的大鼠肝脏糖原含量降低。这些结果表明，卡介苗细胞的某些成分可能增强促分泌剂刺激的胰岛素释放，如此释放的胰岛素可减弱激动剂的某些代谢作用。
