静脉注射胸腺素处理的骨髓细胞后小鼠肿瘤生长的减缓

Decrease of tumor growth in mice after intravenous thymosin-treated bone marrow cell injection.

作者信息

Cupissol D, Rey A, Goldstein A L, Serrou B

出版信息

J Natl Cancer Inst. 1982 Jul;69(1):27-31.

Abstract

The effect of iv injection in C57BL/6 mice of 3X10(7) bone marrow cells preincubated in either thymosin fraction V or thymosin alpha-1 was evaluated on the growth of a 3-methylcholanthrene-induced transplantable tumor in a syngeneic system. The effect was then compared to that elicited by theophylline or levamisole, which both demonstrated thymosin-like action in vitro. The results showed significantly retarded tumor growth (P less than 0.001) and prolonged survival time (P less than 0.001) when thymosin fraction V was used. The same results were obtained with thymosin alpha-1 with use of the same protocol but only one-twentieth of the concentration of fraction V. Theophylline and levamisole demonstrated no antitumor effect.

摘要

评估在C57BL/6小鼠中静脉注射预先在胸腺素组分V或胸腺素α-1中孵育的3×10⁷个骨髓细胞，对同基因系统中3-甲基胆蒽诱导的可移植肿瘤生长的影响。然后将该效果与茶碱或左旋咪唑所引发的效果进行比较，茶碱和左旋咪唑在体外均表现出胸腺素样作用。结果显示，当使用胸腺素组分V时，肿瘤生长显著迟缓（P<0.001）且存活时间延长（P<0.001）。使用相同方案，但仅为组分V浓度的二十分之一的胸腺素α-1也得到了相同结果。茶碱和左旋咪唑未显示出抗肿瘤作用。