Duffield P H, Dougan D F, Wade D N, Duffield A M
Life Sci. 1982 May 17;30(20):1701-5. doi: 10.1016/0024-3205(82)90302-2.
Direct measurement by gas chromatography methane chemical ionization mass spectrometry of alpha-methyldopamine and alpha-methylnorepinephrine in rat striatum has shown the failure of these compounds to be accumulated in vivo after chronic administration of d-amphetamine despite the accumulation of alpha-methyltyramine, an immediate in vitro precursor. Further, both alpha-methyldopamine and alpha-methyltyramine accumulate in rat striatum after administration of alpha-methyltyrosine. These data suggest that, after administration of alpha-methyltyrosine, alpha-methyldopamine is formed via decarboxylation of alpha-methyldopa and not from hydroxylation of alpha-methyltyramine. Finally, our results indicate that alpha-methyldopamine does not play a role in the development of tolerance to d-amphetamine.
通过气相色谱甲烷化学电离质谱法直接测量大鼠纹状体中的α-甲基多巴胺和α-甲基去甲肾上腺素发现，尽管即时体外前体α-甲基酪胺会蓄积，但在长期给予d-苯丙胺后，这些化合物在体内并未蓄积。此外，给予α-甲基酪氨酸后，α-甲基多巴胺和α-甲基酪胺都会在大鼠纹状体中蓄积。这些数据表明，给予α-甲基酪氨酸后，α-甲基多巴胺是通过α-甲基多巴的脱羧作用形成的，而不是由α-甲基酪胺的羟基化作用形成的。最后，我们的结果表明，α-甲基多巴胺在对d-苯丙胺的耐受性发展中不起作用。
