Boulu R G, Plotkine M, Gueniau C, Sofeir M, Wiernsperger N
Pathol Biol (Paris). 1982 May;30(5):278-81.
The effect of indomethacin treatment (4 mg/kg-1, i.v.) on the cerebrocortical post-ischemic reperfusion ischemia (rabbits) or to focal epicerebral ischemia (cats). When administered prior to global ischemia (but not after), indomethacin enhanced the cortical post-ischemic blood flow. No improvement, however, could be observed in the electrocorticogram in either case. Moreover, indomethacin pretreatment did not change the evolution of the cortical tissular pO2 following focal ischemia. It is suggested that, in spite of post-ischemic amelioration of blood flow, indomethacin is unable to improve tissular oxygenation and electrical activity of the cerebral cortex.
吲哚美辛治疗（4毫克/千克，静脉注射）对兔脑皮质缺血后再灌注缺血或猫局灶性大脑皮质缺血的影响。在全脑缺血前（而非缺血后）给予吲哚美辛，可增强皮质缺血后的血流量。然而，在这两种情况下，脑电图均未观察到改善。此外，吲哚美辛预处理并未改变局灶性缺血后皮质组织pO₂的变化。提示尽管吲哚美辛可改善缺血后的血流，但无法改善大脑皮质的组织氧合和电活动。
