Le Poncin-Lafitte M, Grosdemouge C, Rapin J R
Pathol Biol (Paris). 1982 May;30(5):289-93.
In the awake rats, a cerebral ischemia was performed by means of 2,000 microspheres administered into the internal carotid via a chronic catheter. After a coma lasting for a few minutes and a 24-48 h palsy, the Long Evans rats gradually recover a normal behavior. The acquisition of an avoidance response is deeply disturbed by microembolization but the capacities of memorization reappeared with the regression of oedema. 7 days after embolization, the cerebral blood flow in ischemized hemisphere was still significantly decreased, and in spite the glucose consumption was identical in ischemized and non ischemized side. This latter parameter is a better index of the cell activity. This model in the awake rat was proposed for the study of molecules used in cerebral ischemia without interference of anesthetics drugs.
在清醒大鼠中，通过经慢性导管将2000个微球注入颈内动脉来造成脑缺血。经过持续几分钟的昏迷和24 - 48小时的麻痹后，Long Evans大鼠逐渐恢复正常行为。微栓塞严重干扰了回避反应的习得，但随着水肿消退，记忆能力重新出现。栓塞7天后，缺血半球的脑血流量仍显著降低，尽管缺血侧和非缺血侧的葡萄糖消耗量相同。后一个参数是细胞活性的更好指标。该清醒大鼠模型被提出用于研究脑缺血中使用的分子，而不受麻醉药物的干扰。
