离体灌注大鼠肾脏对同源和异源胰岛素的肾处理

Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney.

Schlatter E, Schurek H J, Zick R

Pflugers Arch. 1982 May;393(3):227-31. doi: 10.1007/BF00584074.

Abstract

Renal handling of pig- and rat-insulin was studied in the isolated perfused rat kidney. 2. Metabolic clearance rates of both pig- and rat-insulin exceeded GFR. 3. Peritubular uptake of pig-insulin accounted for 13% of rat-insulin for 31% of the total metabolic clearance. 4. The nonfiltering kidney does not remove insulin from the peritubular circulation. 5. Metabolic clearance rates of pig- and rat-insulin are directly related to GFR. 6. The filtration process seems to be necessary for the uptake of insulin at the peritubular site.

摘要

在离体灌注大鼠肾脏中研究了猪胰岛素和大鼠胰岛素的肾脏处理情况。2. 猪胰岛素和大鼠胰岛素的代谢清除率均超过肾小球滤过率。3. 肾小管周围对猪胰岛素的摄取占大鼠胰岛素总代谢清除率的13%，占总代谢清除率的31%。4. 无滤过功能的肾脏不会从肾小管周围循环中清除胰岛素。5. 猪胰岛素和大鼠胰岛素的代谢清除率与肾小球滤过率直接相关。6. 滤过过程似乎是胰岛素在肾小管周围部位摄取所必需的。