Snider T G, Pierce K R, Adams L G
Am J Vet Res. 1982 Aug;43(8):1363-6.
Neonatally thymectomized and intact Holstein calves were inoculated intradermally with bacille Calmette Guérin mycobacteria at 4 to 6 months of age. The immune response of the calves was evaluated by in vitro lymphocyte stimulation, with a purified protein derivative of Mycobacterium bovis, and by a cervical skin test. Eight of te calves had been previously infected at 7 to 15 weeks of age with bovine viral diarrhea virus. The cutaneous and in vitro immune responses were not different in neonatally thymectomized calves, whether or not they had been previously infected with bovine viral diarrhea virus. However, a prominent histologic difference in the nature of the primary granulomatous lesions was observed in the thymectomized calves. These injection sites were characterized by few lymphocytes and an increased number of multinucleated giant cells. These observations were interpreted as manifestations of a deficient thymus-dependent effector response in the thymectomized calves.
新生期切除胸腺和未切除胸腺的荷斯坦犊牛在4至6月龄时皮内接种卡介苗分枝杆菌。通过用牛分枝杆菌纯化蛋白衍生物进行体外淋巴细胞刺激以及颈部皮肤试验来评估犊牛的免疫反应。其中8头犊牛在7至15周龄时曾感染牛病毒性腹泻病毒。无论之前是否感染过牛病毒性腹泻病毒，新生期切除胸腺的犊牛的皮肤和体外免疫反应并无差异。然而，在切除胸腺的犊牛中观察到原发性肉芽肿病变性质存在显著的组织学差异。这些注射部位的特点是淋巴细胞数量少，多核巨细胞数量增加。这些观察结果被解释为切除胸腺的犊牛中胸腺依赖性效应反应不足的表现。
