The effects of 11-methyl 16,16 dimethyl prostaglandin E2 on canine gastric acid secretion.

11-Methyl 16,16 dimethyl Prostaglandin E2 (TM-PGE2) at peak effectiveness inhibited acid output stimulated submaximally by histamine in the dog by 95 and 84% when administered by the intravenous and oral routes, respectively. Inhibition of secretion was maintained for 1-1/2 hours following intravenous administration while with the oral route, secretory inhibition was still present at the end of two hours after administration of the drug. The degree of inhibition of acid secretion caused by TM-PGE2, its duration of action and the lack of side effects observed following administration of this drug makes it a suitable compound for evaluation as an anti-secretory agent in man.