11-甲基-16,16-二甲基前列腺素E2对人体胃酸分泌的影响。

The effects of 11-methyl 16,16 dimethyl prostaglandin E2 on gastric acid secretion in man.

作者信息

Wilson D E, Winter S L

出版信息

Prostaglandins. 1978 Jul;16(1):127-33. doi: 10.1016/0090-6980(78)90209-5.

Abstract

11-Methyl 16,16 Dimethyl Prostaglandin E2 (TM-PGE) was administered orally to man in dosages of 2.5, 5,7.5 and 10 microgram/kg. Maximal inhibition of basal secretion was 52 and 78% and submaximal histamine-stimulated secretion 45 and 70% for volume and acid output, respectively. Secretory inhibition was observed for approximately two hours after ingestion of the drug. No effect was observed on serum gastrin levels. Side effects occurred with equal frequency in the placebo and drug groups. TM-PGE is well tolerated and inhibits both basal and submaximal histamine-stimulated acid secretion in man. Further evaluation may prove it to be helpful in the clinical treatment of acid hypersecretory states and peptic ulcer disease.

摘要

11-甲基-16,16-二甲基前列腺素E2（TM-PGE）以2.5、5、7.5和10微克/千克的剂量口服给予人体。基础分泌的最大抑制率分别为52%和78%，组胺刺激的次最大分泌量和酸排出量的抑制率分别为45%和70%。服药后约两小时观察到分泌抑制作用。未观察到对血清胃泌素水平有影响。安慰剂组和药物组的副作用发生率相同。TM-PGE耐受性良好，可抑制人体基础和组胺刺激的次最大胃酸分泌。进一步评估可能证明其对胃酸分泌过多状态和消化性溃疡疾病的临床治疗有帮助。