大鼠皮肤移植中的血流、组胺含量及组氨酸脱羧酶活性及其受环孢素A的影响
Blood flow, histamine content and histidine decarboxylase activity in rat skin grafts and their modification by cyclosporin-A.
作者信息
Fan T P, Lewis G P
出版信息
Br J Pharmacol. 1982 Jul;76(3):491-7. doi: 10.1111/j.1476-5381.1982.tb09244.x.
Abstract
1 An attempt has been made to monitor simultaneously the changes in blood flow, histamine content, histidine decarboxylase (HDC) activity and mast cell population in rat skin isografts and allografts. 2 The histamine content in rat skin allografts during rejection was decreased in contrast with our earlier observation in rabbits. 3 Although no definite correlation has been found between blood flow changes, histamine content or HDC activity, a reciprocal relationship appeared to exist between histamine content and HDC activity in the skin grafts, which might be a reflection of the immunosuppressive activity of this amine. 4 The immunosuppressive agent, cyclosporin-A (20 mg/kg daily) was able to prolong skin allograft survival and prevent the changes in histamine and HDC activity in allografts. 5 Possible implications of these findings are discussed in relation to current knowledge concerning the interactions between endothelial cells, lymphocytes and mast cells/basophils in graft rejection.
摘要
- 已尝试同时监测大鼠皮肤同基因移植和异基因移植中血流、组胺含量、组氨酸脱羧酶（HDC）活性及肥大细胞数量的变化。2. 与我们早期在兔子身上的观察结果相反，大鼠皮肤异基因移植在排斥过程中组胺含量降低。3. 尽管在血流变化、组胺含量或HDC活性之间未发现明确的相关性，但皮肤移植中组胺含量与HDC活性之间似乎存在相互关系，这可能反映了该胺的免疫抑制活性。4. 免疫抑制剂环孢素A（每日20mg/kg）能够延长皮肤异基因移植的存活时间，并防止异基因移植中组胺和HDC活性的变化。5. 结合目前关于内皮细胞、淋巴细胞和肥大细胞/嗜碱性粒细胞在移植排斥中相互作用的知识，讨论了这些发现的可能意义。
相似文献
1
Blood flow, histamine content and histidine decarboxylase activity in rat skin grafts and their modification by cyclosporin-A.大鼠皮肤移植中的血流、组胺含量及组氨酸脱羧酶活性及其受环孢素A的影响
Br J Pharmacol. 1982 Jul;76(3):491-7. doi: 10.1111/j.1476-5381.1982.tb09244.x.
2
Histamine content and histidine decarboxylase activity in the spleen of the magnesium-deficient rat: comparison with the skin and peritoneal mast cells.
Jpn J Pharmacol. 1984 Sep;36(1):1-6. doi: 10.1254/jjp.36.1.
3
Demonstration of histaminergic neurons in horizontal cells of guinea pig retina.豚鼠视网膜水平细胞中组胺能神经元的显示
Brain Res. 1987 May 5;410(2):269-74. doi: 10.1016/0006-8993(87)90324-6.
4
Histaminergic cells in the choroid plexus of rat.大鼠脉络丛中的组胺能细胞。
J Chem Neuroanat. 1988 Jan-Feb;1(1):53-7.
5
Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo-oxygenase products in rat skin allografts.环孢素A及花生四烯酸代谢抑制剂对大鼠皮肤同种异体移植血流及环氧化酶产物的影响
Br J Pharmacol. 1984 Feb;81(2):361-71. doi: 10.1111/j.1476-5381.1984.tb10087.x.
6
A simple method for the determination of polyamines and histamine and its application to the assay of ornithine and histidine decarboxylase activities.一种测定多胺和组胺的简便方法及其在鸟氨酸和组氨酸脱羧酶活性测定中的应用。
Methods Enzymol. 1983;94:42-7. doi: 10.1016/s0076-6879(83)94008-9.
7
[Detection and significance of histidine decarboxylase (HDC) in "Klebsiella", "Enterobacter" and "Serratia" (author's transl)].“克雷伯菌属”、“肠杆菌属”和“沙雷菌属”中组氨酸脱羧酶（HDC）的检测及其意义（作者译）
Ann Microbiol (Paris). 1979 Apr;130A(3):385-8.
8
Increase in histidine decarboxylase activity in mouse skin after application of tumor promoters.应用肿瘤启动剂后小鼠皮肤中组氨酸脱羧酶活性增加。
Princess Takamatsu Symp. 1983;14:327-34.
9
Presence and localization of histidine decarboxylase enzyme (HDC) and histamine in Tetrahymena pyriformis.梨形四膜虫中组氨酸脱羧酶（HDC）和组胺的存在及定位
Cell Biol Int. 1998;22(7-8):493-7. doi: 10.1006/cbir.1998.0280.
10
Histamine, histidine decarboxylase and histamine-N-methyltransferase in brain areas of spontaneously hypertensive rats.自发性高血压大鼠脑区中的组胺、组氨酸脱羧酶和组胺-N-甲基转移酶
Naunyn Schmiedebergs Arch Pharmacol. 1988 Nov;338(5):573-6. doi: 10.1007/BF00179332.
引用本文的文献
1
Proceedings of the British Pharmacological Society, University of Cambridge, 6th-8th April, 1983. Abstracts.《英国药理学会会刊》，剑桥大学，1983年4月6日至8日。摘要
Br J Pharmacol. 1983 Jun;79 Suppl(Suppl):188P-425P.
2
Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo-oxygenase products in rat skin allografts.环孢素A及花生四烯酸代谢抑制剂对大鼠皮肤同种异体移植血流及环氧化酶产物的影响
Br J Pharmacol. 1984 Feb;81(2):361-71. doi: 10.1111/j.1476-5381.1984.tb10087.x.
3
Effect of cyclosporin A on rat mucosal mast cells and the associated protease RMCPII.环孢素A对大鼠黏膜肥大细胞及相关蛋白酶RMCPII的影响。
Clin Exp Immunol. 1988 Apr;72(1):136-40.
4
Quantitative in-vivo studies on angiogenesis in a rat sponge model.大鼠海绵模型中血管生成的定量体内研究。
Br J Exp Pathol. 1987 Dec;68(6):755-66.
本文引用的文献
1
Evidence that induced histamine is an intrinsic regulator of the microcirculatory system.诱导组胺是微循环系统内在调节因子的证据。
Am J Physiol. 1962 Jan;202:66-72. doi: 10.1152/ajplegacy.1962.202.1.66.
2
A method for the fluorometric assay of histamine in tissues.一种用于组织中组胺荧光测定的方法。
J Pharmacol Exp Ther. 1959 Nov;127:182-6.
3
Wound healing as on rate of histamine formation.伤口愈合与组胺形成速率的关系。 （原英文表述不太准确完整，推测其可能想表达的是伤口愈合与组胺形成速率之间的关系之类的意思，以上译文是基于此进行的完善翻译）
Lancet. 1960 Jul 30;2(7144):230-4. doi: 10.1016/s0140-6736(60)91426-4.
4
The distribution and fate of radioactive histamine in the rat.放射性组胺在大鼠体内的分布与归宿
J Physiol. 1959 Oct;147(3):437-49. doi: 10.1113/jphysiol.1959.sp006254.
5
HISTAMINE IN FULL-THICKNESS SKIN AUTOGRAFTS OF RAT.大鼠全层皮肤自体移植中的组胺
Proc Soc Exp Biol Med. 1964 Dec;117:705-8. doi: 10.3181/00379727-117-29673.
6
Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells.诱导性T淋巴细胞合成一种刺激克隆肥大细胞增殖的因子。
Nature. 1981 May 28;291(5813):332-4. doi: 10.1038/291332a0.
7
Histamine production during the anti-allograft response. Demonstration of a new lymphokine enhancing histamine synthesis.抗同种异体移植反应过程中的组胺产生。一种增强组胺合成的新淋巴因子的证实。
J Exp Med. 1981 Feb 1;153(2):293-309. doi: 10.1084/jem.153.2.293.
8
Role of the basophilic leukocyte in allograft rejection.嗜碱性白细胞在同种异体移植排斥反应中的作用。
J Immunol. 1971 Jan;106(1):279-81.
9
Histidine decarboxylase activity of autografted and allografted rat skin.自体移植和异体移植大鼠皮肤的组氨酸脱羧酶活性
Transplantation. 1969 Feb;7(2):99-104. doi: 10.1097/00007890-196902000-00002.
10
The continuous bioassay of the release and disappearance of histamine in the circulation.组胺在循环系统中释放与消失的连续生物测定。
Br J Pharmacol. 1973 Nov;49(3):543-53. doi: 10.1111/j.1476-5381.1973.tb17265.x.
Zotero 插件