Chuaqui P, Levy R
Br J Psychiatry. 1982 May;140:464-9. doi: 10.1192/bjp.140.5.464.
Plasmas of 12 patients currently taking part in a double-blind trial of lecithin in senile or presenile dementia of Alzheimer type were analysed for plasma choline levels at fixed intervals during lecithin treatment. The values were not maintained at a constant level and showed a decline after one or two months of treatment, often followed by a subsequent rise. Possible explanations for this observation are given, and its significance to the treatment of dementia discussed.
对12名目前正在参与一项关于卵磷脂治疗阿尔茨海默型老年性或早老性痴呆双盲试验的患者血浆,在卵磷脂治疗期间按固定间隔分析其血浆胆碱水平。这些数值并未维持在恒定水平,在治疗一两个月后呈现下降,随后常常又上升。文中给出了对这一观察结果的可能解释,并讨论了其对痴呆治疗的意义。