Goldin A, Schabel F M
Cancer Treat Rep. 1981;65 Suppl 3:11-9.
Animal chemotherapy studies have contributed significantly to clinical concepts in tumor therapy. Preclinical investigations have led to the discovery of new drugs and have demonstrated that it is possible to cure advanced metastatic neoplasia. A fundamental clinical concept stemming from animal chemotherapy studies is that increased selectivity and improved therapeutic effectiveness of antitumor agents may result from appropriate pharmacologic, biochemical, and biologic manipulation of the host-tumor drug relationship. Clinically important factors that may increase antitumor drug selectivity are reviewed and pertinent studies in animal model systems are cited.
动物化疗研究对肿瘤治疗的临床理念做出了重大贡献。临床前研究促成了新药的发现，并证明治愈晚期转移性肿瘤是可能的。源于动物化疗研究的一个基本临床理念是，通过对宿主 - 肿瘤 - 药物关系进行适当的药理、生化和生物学调控，可能提高抗肿瘤药物的选择性并改善治疗效果。本文综述了可能增加抗肿瘤药物选择性的临床重要因素，并引用了动物模型系统中的相关研究。
