Hammond B R, Bhattacherjee P
Curr Eye Res. 1981;1(11):683-5. doi: 10.3109/02713688109001873.
A method has been developed for the intraocular administration of small volumes (0.5-1.5 microliters) in small animal species such as guniea pigs and rats. The method was found to yield reproducible injection volumes and resulted in minimal ocular trauma. The aqueous humor of eyes injected with saline contained normal levels of protein and was free of white blood cells. Responses to Prostaglandin E2 and E.Coli endotoxin were dose-dependent and as expected.
已经开发出一种用于在豚鼠和大鼠等小型动物物种中进行小体积（0.5 - 1.5微升）眼内给药的方法。发现该方法能产生可重复的注射体积，且导致的眼外伤最小。注射生理盐水的眼睛房水中蛋白质水平正常且无白细胞。对前列腺素E2和大肠杆菌内毒素的反应呈剂量依赖性，且符合预期。
