McElnay J C, Smith G D, Helling D K
Drug Intell Clin Pharm. 1982 Jul-Aug;16(7-8):533-42. doi: 10.1177/106002808201600701.
A practical guide to the drug interactions involving theophylline kinetics is presented. The text is classified into three categories--pharmacokinetics, pharmacodynamics, and miscellaneous drug interactions. In the discussion of pharmacokinetics, interactions are classified according to site; in vitro, intestinal, metabolic, protein binding, and renal mechanisms are considered. The pharmacodynamic section concentrates on possible additive effects of theophylline and other commonly used bronchodilators, while in the miscellaneous section, discussion is devoted to those interactions involving allergic skin testing and changed results of commonly used assay methods for theophylline. Increased awareness of possible interactions should lead to a more critical approach to theophylline prescribing, particularly in those cases where an unexpected therapeutic effect (or theophylline serum concentration) is obtained during the treatment of asthmatic patients.
本文介绍了一份关于涉及茶碱动力学的药物相互作用的实用指南。文本分为三类——药代动力学、药效学和其他药物相互作用。在药代动力学的讨论中，相互作用根据部位进行分类；考虑了体外、肠道、代谢、蛋白质结合和肾脏机制。药效学部分重点关注茶碱与其他常用支气管扩张剂可能的相加作用，而在其他部分，则讨论了涉及过敏皮肤试验和茶碱常用检测方法结果改变的相互作用。对可能相互作用的认识提高应导致在茶碱处方时采取更审慎的方法，特别是在哮喘患者治疗期间获得意外治疗效果（或茶碱血清浓度）的情况下。
