抗肿瘤抗生素的检测与测定

Detection and assay of antitumor antibiotics.

作者信息

Hanka L J, Kuentzel S L, Martin D G, Wiley P F, Neil G L

出版信息

Recent Results Cancer Res. 1978;63:69-76. doi: 10.1007/978-3-642-81219-4_7.

Abstract

Cell culture techniques and antimicrobial systems can be used as detection systems for new antibiotic structures. Antimicrobial systems by virtue of their speed, economy, ease of use, and adaptation to chromatographic (bioautographic) techniques are definitely superior for assay and for dereplication purposes. A prescreen assay system which combines the advantages and minimizes the disadvantages of the two approaches is described.

摘要

细胞培养技术和抗菌系统可作为新型抗生素结构的检测系统。抗菌系统凭借其速度、经济性、易用性以及对色谱（生物自显影）技术的适应性，在分析和去重复目的方面绝对更具优势。本文描述了一种结合了这两种方法的优点并将缺点最小化的预筛选分析系统。